BIOAVAILABILITY ENHANCEMENT OF REPAGLINIDE USING NANO LIPID CARRIER: PREPARATION CHARACTERIZATION AND IN VIVO EVALUATION

Objective: The aim of this study to manufacture the prolonged release lipid nanoparticle (Solid and nanostructure carrier) repaglinide for enhance oral bioavailability. Methods: Solid nanoparticles (SLN) Nanostructured carriers (NLC) were prepared by slight modification in solvent diffusion method. core material used as cetyl alcohol while blend with oleic acid was preparation NLC dispersion. Tween 80 utilized a Surfactant lecithin cosurfactant both types formulation. Lipid characterized size distribution, entrapment parameter, zeta potential, surface morphology, vitro drug stability study. Pharmacodynamic also performed evaluate antidiabetic activity repaglinide-loaded nanodispersion. Results: It observed that matrix-based SLN having significant particle (157.8±15.8 nm 238.4±48.2 dispersion), efficacy 79.82±0.84% 72.04±1.03% Zeta potential report clarifying formulation is stable state prolong time. SEM distribution evaluated Malvern instrument. confirmed be after 180 d storage, according data from vivo assessment showed Repaglinide-loaded dispersion able reduce blood sugar level. Interestingly, case RPG-SLN, RPG-NLC-I RPG-NLC-II groups, average values at all-time intervals significantly less than basal glucose value (p<0.05). Conclusion: ability control make nano suitable resolve poor bioavailability repaglinide.